The sinoatrial node, a heterogeneous pacemaker structure
نویسندگان
چکیده
منابع مشابه
The sinoatrial node, a heterogeneous pacemaker structure.
This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing. Experimental studies on the single SA nod...
متن کاملSCN5A and sinoatrial node pacemaker function.
The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells. Although iNa has been recorded from sinoatrial (SA) node pacemaker cells, its precise role in SA node p...
متن کاملElectrophysiology and pacemaker function of the developing sinoatrial node.
The sinoatrial node performs its task as a cardiac impulse generator throughout the life of the organism, but this important function is not a constant. Rather, there are significant developmental changes in the expression and function of ion channels and other cellular elements, which lead to a postnatal slowing of heart rate and may be crucial to the reliable functioning of the node during ma...
متن کاملFactors controlling pacemaker action in cells of the sinoatrial node.
• Studies of the effects of imposed drive on isolated mammalian sinoatrial (SA) node pacemaker cells were undertaken as a result of the observed effects of rapid drive imposed on in situ pacemakers. Such studies are not new since Gaskell in 1884 observed that tetanic stimulation of the turtle sinus venosus or atria had an inhibitory effect on pacemaker function. In the most recent studies of th...
متن کاملPacemaker current (I(f)) in the human sinoatrial node.
AIMS Animal studies revealed that the hyperpolarization-activated pacemaker current, I(f), contributes to action potential (AP) generation in sinoatrial node (SAN) and significantly determines heart rate. I(f) is becoming a novel therapy target to modulate heart rate. Yet, no studies have demonstrated that I(f) is functionally present and contributes to pacemaking in human SAN. We aimed to stud...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2000
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(00)00135-8